Critical Infrastructure

Uninterrupted Excellence: Holistic Critical Infrastructure for Life Science Campuses

In the demanding world of biopharmaceutical manufacturing and life science research, operational continuity isn’t just a goal—it’s a fundamental requirement.

Every minute of downtime can translate into significant losses, impacting production, research, and ultimately, patient well-being. That’s why Genesis AEC specializes in designing, building, validating, and maintaining integrated critical infrastructure that ensures your life science campus operates with unparalleled reliability and strict regulatory compliance. We understand the unique challenges of pharmaceutical environments, where mission-critical power systems and exceptionally reliable utilities must adhere to the highest standards, including FDA and FDA Annex 1. Our holistic approach delivers the compliant and sustainable infrastructure you need to thrive.

What Makes Genesis AEC Your Ideal Partner?

  • Tier IV-Level Reliability: Experience near-perfect uptime with our 2N/N+1 redundancy and automated backup systems, ensuring up to 99.995% uptime. This limits unplanned interruptions to under 26 minutes per year, safeguarding your critical processes.
  • Validated Compliance: Every utility system we design and implement meets stringent Annex 1 aseptic requirements and 21 CFR 211 standards. We provide full URS→FAT→SAT documentation, ensuring a seamless path to compliance.
  • Scalable & Sustainable Design: Our modular utility and power platforms are engineered to scale effortlessly with your tenant or process growth. Plus, they support the integration of renewable energy and help you achieve your carbon reduction targets.
  • Turnkey Delivery & Single-Point Accountability: From initial master planning to digital twin handover, you benefit from one-engineer, single-point accountability. This streamlined approach minimizes complexities and maximizes efficiency.

Our Comprehensive Critical Infrastructure Solutions

Utility Master Planning & Hydraulic Modeling

We lay the groundwork for optimal performance by digitally mapping every pipe, valve, pump, and utility header across your campus. Using advanced tools like PipeFlo® software and our proprietary PharmaWater Pro™, our services include precision hydraulic modeling, creating a digital twin of your chilled water, cooling tower water, and boiler feedwater/condensate transfer systems. We conduct detailed system documentation and on-site surveys, compiling all available design and as-built information. Through performance optimization simulations, calibrated with real-world operational data, we can:

  • Proactively model the impacts or system failures before construction begins.
  • Precisely size your systems to reduce pump horsepower and piping costs while optimizing distribution.
  • Identify and resolve hydraulic issues that may lead to equipment trips or inefficiencies.
  • Evaluate opportunities for reducing energy costs across your entire campus.

We also provide continuous hydraulic model updates as your site undergoes renovations and new construction, performing peak demand simulations to confirm system operability and identify deficiencies. Tangible Results: Our hydraulic optimization strategies can lead to up to 1.9 M kWh/year in energy savings and $1.2 M annually in operational cost reductions.

Generation, Storage & Distribution of Critical Utilities

We engineer and deliver high-purity systems essential for your operations, including:

  • Water for Injection (WFI), Purified Water (PW), High Purity Water (HPW), clean and pure steam
  • Process gas delivery
  • Clean-in-Place/Sterilize-in-Place (CIP/SIP) systems for sanitation
  • Advanced Waste Management (inactivation, neutralization)

We design these systems for efficient operation and ease of service, significantly reducing your O&M overhead and ensuring uninterrupted GMP compliance. Our expertise extends to utility system integration for critical connections like chilled and condenser water, electrical distribution, and steam/condensate piping. We specialize in seamless integration of new equipment without disrupting existing operations. This includes the decommissioning of legacy steam absorption chillers and their replacement with high-efficiency electric chillers, alongside the optimization of your Sequence of Operations (SOO) to strategically leverage energy sources like COGEN waste steam heat for chilled water production.

Critical Power Architecture & Advanced Controls

Power disruptions are not an option. We deploy N+1 or 2N redundancy across all critical components, including UPS, generators, Automatic Transfer Switches (ATS), and Medium Voltage/Low Voltage (MV/LV) switchgear.

Uninterrupted Power Supply:

Benefit from dual-source feeders and automatic transfer systems that keep your critical loads online without interruption. Our online double-conversion UPS and power conditioning solutions guard against all voltage anomalies.

Comprehensive Monitoring:

Full power monitoring and control systems ensure continuous compliance and peak performance. We provide real-time power monitoring and alerts to detect and fix deviations before equipment trips.

Benefit: Achieve campus-scale resilience with a near-zero risk of power failure. Our cleanroom resilience solutions are built-in, safeguarding airflow and aseptic compliance during power fluctuations. Even tiny voltage dips or frequency shifts can derail pharmaceutical manufacturing, especially in aseptic processes. This can lead to sensitive equipment tripping offline (VFDs, PLCs, clean-room ventilators, cooling systems, and production machines) and a loss of cleanroom integrity, potentially collapsing positive pressure and triggering lengthy requalification, risking product sterility. Unplanned shutdowns can also result in costly batch loss and delays.

Fuel Conversion & Carbon Reduction Initiatives

Modernize your energy infrastructure, achieve Net Zero/ESG goals, and contribute to a greener future. We help you:

  • Transition Boilers: Convert from oil to natural gas or renewables-ready electric systems, achieving 30–40% CO₂ reduction with typical paybacks under 3 years.
  • Integrate Sustainable Solutions: Incorporate heat-recovery chillers, CHP (Combined Heat and Power) possibilities, and strategic solar interconnection planning.

Our services include AC power interconnection and electric service upgrades, coordinated diligently with utility companies. We also support the integration of large-scale solar farms into existing operations, such as a 4-megawatt solar farm. The phasing out of legacy energy streams that contribute to GHG emissions and their replacement with more sustainable alternatives is a focus, setting a clear path for reduced site GHG emissions and overall carbon footprint.

Tenant-Ready Utility and Power Infrastructure

Streamline your leasing process and attract top-tier tenants with our “plug-and-play” solutions. We install:

  • Pre-engineered headers, stub-outs, and metering
  • Built-in backup capacities

This enables new tenants to connect and operate labs immediately, significantly speeding up move-in times and boosting leasing readiness.

Aging Infrastructure Modernization

Upgrade your existing infrastructure without disrupting critical GMP production. We execute phased updates to:

  • Boilers, Chillers, Tanks
  • VFDs (Variable Frequency Drives) and MCCs (Motor Control Centers)

Right-sizing and VFD retrofits often result in up to 50% reduction in pump energy use and substantial O&M savings. Our modernization projects lead to a highly efficient chilled water system, resulting in reduced operational costs, improved energy efficiency, and a lower carbon footprint.

GMP System Validation Services

Our process ensures your systems are fully validated and ready for optimal performance. We provide:

  • Full User Requirement Specification (URS) → Factory Acceptance Test (FAT) → Site Acceptance Test (SAT) workflows for both utility and power systems.
  • Comprehensive Turnover Documentation: Including digital twins, asset tagging, and condition-monitoring dashboards.

This ensures long-term compliance, future reliability, and streamlined maintenance for your facility.

Representative Project Examples (Critical Infrastructure Tag)

  • cGMP BIOTECHNOLOGY FACILITY: This 338,000 sf facility would have extensive critical infrastructure requirements including purified water systems, process gases, and backup power, all engineered by Genesis.
  • MULTI-NATIONAL PHARMACEUTICAL COMPANY: A preclinical research facility requires reliable critical infrastructure, especially for laboratory utilities and power. Genesis provided full engineering design.
  • BRISTOL-MYERS SQUIBB (New Brunswick, NJ): The full building renovation and expansion of a 100,000 sf chemical lab facility would involve significant upgrades and redesign of critical utilities to meet current standards. Genesis provided full engineering services.

Operational Benefits

Partnering with Genesis delivers measurable benefits:

  • Less than 30 minutes per year of unplanned downtime due to Tier IV-equivalent reliability.
  • 1.9 M kWh/year saved in electrical energy from hydraulic optimization.
  • Up to 50% pump energy reduction and significant operational and maintenance (O&M) savings.
  • Up to 40% CO₂ reduction with boiler fuel conversions.
  • Fully GMP-compliant utilities and power systems, validated to Annex 1 and 21 CFR standards.

Ready to Elevate Your Critical Infrastructure?

Ensure continuous operation, regulatory compliance, and long-term sustainability across your entire life science campus. Connect with our Critical Infrastructure Team today and secure your operational future.