Leaders in Life Sciences Representative Projects

Takeda - Phased Chiller Plant Upgrade

Phased Chiller Plant Upgrade

Maintaining Continuous Manufacturing Operations

The Critical Infrastructure team at Genesis designed and executed a complex chiller plant upgrade and relocation for Takeda’s Building 5. facility. This project addressed critical operational inefficiencies and expanded thermal load capacity—all while ensuring zero downtime for essential pharmaceutical manufacturing.

A primary challenge was the high-stakes conversion of a second-floor office space into a heavy-duty, code-compliant chiller room. This required navigating intricate electrical, mechanical, and structural constraints within an active facility.

Key Technical Milestones:

  • Mechanical Systems & Multi-Temp Cooling: We installed nine new high-efficiency chillers (ranging from 200 to 400 tons) and twelve pumps. The system was engineered to deliver precise process cooling at three distinct setpoints: at +6°C, -6°C, and -12°C.

  • Structural Reinforcement: To support the massive operational loads of industrial chillers in a former office footprint, our team performed critical structural slab reinforcement on the second floor.

  • Phased Decommissioning: To guarantee operational continuity, the new infrastructure was fully commissioned before any of the eleven legacy chillers and pumps were removed from service.

Project Results: Reliability Without Disruption

Through strategic phased execution, Genesis delivered a modern, high-capacity cooling solution tailored to the rigorous demands of life sciences manufacturing:

  • Zero Production Downtime: Manufacturing remained online throughout the entire transition.
  • Increased Thermal Capacity: Expanded cooling loads to support future facility growth.

  • Legacy Equipment Removal: Streamlined operations by removing 22 pieces of outdated legacy equipment post-commissioning.

  • Expertise in Critical Infrastructure: This project highlights our ability to execute “live” system swaps in sensitive environments where environmental control is non-negotiable.

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